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1α Hydroxyvitamin D3-d6

Catalog No. V09106
Name 1α Hydroxyvitamin D3-d6
Synonyms Alfacalcidol-d6; 1α-Hydroxycholecalciferol-d6; Alpharol-d6; Alpha D3-d6; Etalpha-d6; 1-Hydroxyvitamin D3-d6
CAS No. 41294-56-8 (Unlabeled)
Purity 99+%
Formula C27H38D6O2
Mol. Weight 406.67
Storage -20°C Freezer
Appearance White solid
MSDS Inquire



Additional information


Deuterated 1-alpha-Hydroxy Vitamin D3 – stable isotope. Ideal for use as analytical standard. Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity. 1-Hydroxy Vitamin D3 is a synthetic prodrug which is converted by cytochrome P450 isoforms to the vitamin D receptor agonist 1,25-dihydroxy vitamin D3 in vivo. Such prodrugs are effective in suppressing the synthesis and secretion of parathyroid hormone in secondary hyperparathyroidism, an action which requires the vitamin D receptor. 1-Hydroxy Vitamin D3 supports bone growth both in postmenopausal women and in glucocorticoid-induced osteoporosis. It also provides renal and cardiovascular protection during chronic kidney disease.


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2. Oral calcitriol versus oral alfacalcidol for the treatment of secondary hyperparathyroidism in patients receiving hemodialysis: a randomized, crossover trial". Can J Clin Pharmacol. 15 (1): e36–e43. 2008.
3. Alfacalcidol treatment restores derailed immune-regulation in patients with undifferentiated connective tissue disease, Autoimmunity Reviews, August 2010.