Additional information
| Description | 7-Octynoic acid (compound 42) plays a pivotal role as a linker in PROTACs, facilitating the synthesis of diverse compounds in this category. PROTACs are characterized by their structure, comprising two distinct ligands connected via a linker: one ligand binds to an E3 ubiquitin ligase, while the other targets a specific protein for degradation through the cell's ubiquitin-proteasome system [1]. Moreover, 7-Octynoic acid serves as a reagent in click chemistry, featuring an Alkyne group that enables its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc). This reaction is instrumental in conjugating molecules containing Azide groups, a critical aspect of molecular synthesis [1]. |
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| Reference | [1]. Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17. |
