Additional information
| Description | 1,25-dihydroxy Vitamin D2 is the active circulating metabolite of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D-hydroxylase in the kidney.1 By binding to the vitamin D receptor (VDR), 1,25-dihydroxy Vitamin D2 activates VDR to interact with the retinoid X receptor (RXR), forming the VDR/RXR/cofactor complex, which regulates gene transcription.2 Because 1,25-dihydroxy Vitamin D2 circulates at picomolar concentrations and is highly lipophilic, it is difficult to quantify. |
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| References | Lam, H., et al.: Science, 186, 1038 (1974), Dilworth, F., et al.: J. Biol. Chem., 270, 16766 (1995), Horst, R., et al.: Biochem. Pharmacol. 60, 701 (2000), Horst, R., et al.: J. Cell Biochem., 88, 282 (2003) |
