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1α, 25 Dihydroxyvitamin D2

Catalog No. V09115
Name 1α,25-Dihydroxyvitamin D2
Synonyms 1α,25-Dihydroxycalciferol; Ercalcitriol; (1α,3β,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3,25-triol
CAS No. 60133-18-8
Purity 99+%
Formula C28H44O3
Mol. Weight 428.65
Storage -20°C Freezer
Appearance White solid
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Additional information


1,25-dihydroxy Vitamin D2 is the active circulating metabolite of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D-hydroxylase in the kidney.1 By binding to the vitamin D receptor (VDR), 1,25-dihydroxy Vitamin D2 activates VDR to interact with the retinoid X receptor (RXR), forming the VDR/RXR/cofactor complex, which regulates gene transcription.2 Because 1,25-dihydroxy Vitamin D2 circulates at picomolar concentrations and is highly lipophilic, it is difficult to quantify.


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