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1α-Hydroxyvitamin D2

Catalog No. V09113
Name 1α-Hydroxyvitamin D2
Synonyms Doxercalciferol; Hectorol; 1-Hydroxyergocalciferol; TSA 840
CAS No. 54573-75-0
Purity 99+%
Formula C28H44O2
Mol. Weight 412.65
Storage -20°C Freezer
Appearance White solid
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Additional information


Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity. 1-Hydroxy Vitamin D2 is a synthetic prodrug of the active 1,25-dihydroxy vitamin D2, as well as of other active metabolites. It is used to suppress the synthesis and secretion of parathyroid hormone in secondary hyperparathyroidism, an action which requires vitamin D receptor. 1-Hydroxy Vitamin D2 is effective in stimulating bone growth and, in combination therapy with angiotensin receptor blockers, ameliorates albuminuria and glomerulosclerosis associated with diabetic nephropathy. It also inhibits the growth of certain blastomas and prostate cancer cells.


1. Brown et al (2006) The vitamin D prodrugs 1α(OH)D2, 1α(OH)D3 and BCI-210 suppress PTH secretion by bovine parathyriod cells. Nephrol.Dial.Transplant. 21 644 PMID: 16221703.
2. Noonan et al (2008) Differential effects of vitamin D receptor activators on aortic calcification and pulse wave velocity in uraemic rats. Nephrol.Dial.Transplant. 23 3824 PMID: 18644798.