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1α, 25 Dihydroxyvitamin D2-d6

Catalog No. V09116
Name 1α,25-Dihydroxyvitamin D2-d6
Synonyms 1α,25-Dihydroxycalciferol-d6; Ercalcitriol-d6; (1α,3β,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3,25-triol
CAS No. 60133-18-8 (Unlabeled)
Purity 99+%
Formula
C28H38D6O3
Mol. Weight 434.68
Storage -20°C Freezer
Appearance White solid
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Description

1,25-dihydroxy Vitamin D2 is the active circulating metabolite of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D-hydroxylase in the kidney.1 By binding to the vitamin D receptor (VDR), 1,25-dihydroxy Vitamin D2 activates VDR to interact with the retinoid X receptor (RXR), forming the VDR/RXR/cofactor complex, which regulates gene transcription.2 Because 1,25-dihydroxy Vitamin D2 circulates at picomolar concentrations and is highly lipophilic, it is difficult to quantify.

References

Lam, H., et al.: Science, 186, 1038 (1974), Dilworth, F., et al.: J. Biol. Chem., 270, 16766 (1995), Horst, R., et al.: Biochem. Pharmacol. 60, 701 (2000), Horst, R., et al.: J. Cell Biochem., 88, 282 (2003)