Additional information
| Biological Activity | Apoptosis activator; encourages the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Promotes procaspase-9 processing and subsequent caspase-3 activation. Stimulates apoptosis in tumor cells (IC50 = 4 – 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM). |
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| References | Jayaraman and Pike (2009) Progesterone attenuates oestrogen neuroprotection via down regulation of oestrogen receptor expression in cultured neurones. J. Neuroendocrinol. 21 77. Alavian et al (2009) Elevtaed p75NTR expression causes death of engrailed-def |
