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Apoptosis Activator 2 / 1-(3,4-Dichloro-benzyl)-1H-indole-2,3-dione

Catalog no. AC12001
Name Apoptosis Activator 2 / 1-(3,4-Dichloro-benzyl)-1H-indole-2,3-dione
CAS number 79183-19-0
MFCD Number
Formula C15H9Cl2NO2
FW 306.14
Cofa/NMR, Batch#:

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Additional information

Biological Activity

Apoptosis activator; encourages the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Promotes procaspase-9 processing and subsequent caspase-3 activation. Stimulates apoptosis in tumor cells (IC50 = 4 – 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM).


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