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Calcipotriol Impurity D

Catalog No. V09125
Name Calcipotriol Impurity D
Synonyms 24-Epi-Calcipotriol;Calcipotriol EP Impurity D;(E)-5-((E)-2-(1-((E)yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methyldiol; 24R-Calcipotriol; 24-Epi-Calcipotriol
CAS No. 112827-99-3
Purity 99+%
Formula
C27H40O3
Mol. Weight 412.62
Storage -20°C Freezer
Appearance White solid
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$240.00 – $1,500.00

SKU: N/A Categories: , ,

Additional information

Description

24R-Calcipotriol (PRI 2202) is an impurity found in Calcipotriol, also known as Calcipotriene or MC 903, which functions as a ligand for VDR-like receptors. It has an IC50 value as a Vitamin D3 analog that minimally affects calcium homeostasis while regulating cell differentiation and proliferation. Calcipotriol demonstrates antiproliferative activity against various cancer cell lines, including human HL-60, HL60/MX2, MCF-7, T47D, SCC-25, and mouse WEHI-3 cells.[1,2,3]
References

1]. Gocek, Elzbieta; Kielbinski, Marek; Baurska, Hanna et al. Different susceptibilities to 1,25-dihydroxyvitamin D3-induced differentiation of AML cells carrying various mutations. Leukemia Research (2010), 34(5), 649-657.
[2]. Gocek, Elzbieta; Kielbinski, Marek; Wylob, Paulina et al. Side-chain modified vitamin D analogs induce rapid accumulation of VDR in the cell nuclei proportionately to their differentiation-inducing potential. Steroids (2008), 73(14), 1359-1366.
[3]. Wietrzyk, Joanna; Nevozhay, Dmitry; Filip, Beata et al. The antitumor effect of lowered doses of cytostatics combined with new analogs of vitamin D in mice. Anticancer Research (2007), 27(5A), 3387-3398.

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