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1α Hydroxyvitamin D3

Catalog No. V09105
Name 1α Hydroxyvitamin D3
Synonyms Alfacalcidol; 1α-Hydroxycholecalciferol; Alpharol; Alpha D3; Etalpha; Oxydevit; 1-Hydroxyvitamin D3
CAS No. 41294-56-8
Purity 99+%
Formula C27H44O2
Mol. Weight 400.64
Storage -20°C Freezer
Appearance White solid
MSDS Inquire

$25.00$125.00

Additional information

Description

Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity. 1-Hydroxy Vitamin D3 is a synthetic prodrug which is converted by cytochrome P450 isoforms to the vitamin D receptor agonist 1,25-dihydroxy vitamin D3 in vivo. Such prodrugs are effective in suppressing the synthesis and secretion of parathyroid hormone in secondary hyperparathyroidism, an action which requires the vitamin D receptor. 1-Hydroxy Vitamin D3 supports bone growth both in postmenopausal women and in glucocorticoid-induced osteoporosis. It also provides renal and cardiovascular protection during chronic kidney disease.

References

1.Biological effects of various regimes of 25-hydroxyvitamin D3 (calcidiol) administration on bone mineral metabolism in postmenopausal women". Clin Cases Miner Bone Metab. 6 (2): 169–173. 2009. PMC 2781231 Freely accessible. PMID 22461169.
2. Oral calcitriol versus oral alfacalcidol for the treatment of secondary hyperparathyroidism in patients receiving hemodialysis: a randomized, crossover trial". Can J Clin Pharmacol. 15 (1): e36–e43. 2008.
3. Alfacalcidol treatment restores derailed immune-regulation in patients with undifferentiated connective tissue disease, Autoimmunity Reviews, August 2010.